Method of producing L-aspartyl-D-alanine-N-(thiethane-3-yl)-amides

US5874121A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Karlheinz Drauz · Alzenau, DE
• Gunter Knaup · Bruchköbel, DE
• Stefan Retzow · Alzenau, DE
• Michael Schwarm · Alzenau, DE
• Christoph Weckbecker · Gelnhausen, DE

Key dates

• Filing date: Nov 21, 1997
• Grant date: Feb 23, 1999
• Expiry date: Nov 21, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention concerns a method of producing L-aspartyl-D-alanine-N-(thietane-3-yl) amides of general formula I by reacting D-alanine-thietane amides of general formula II with oxazolidinone compounds of general formula III in an inert organic solvent, wherein R.sup.1 stands for H or a selectively separable protective group, R.sup.2 -R.sup.5 independently of one another, are identical or different and stand for H or linear or branched C.sub.1 -C.sub.4 -alkyl, and R.sup.6 and R.sup.7, independently of each other, are identical or different and stand for H, linear or branched C.sub.1 -C.sub.4 -alkyl, aryl or a group which activates the carbonyl group. ##STR1##