Protease deletion

US5874278A · kind A · utility

Assignee

• OmniGene Inc. · US

Inventors

• Alan Sloma · Davis, US
• Gerald A. Rufo, Jr. · Burlington, US
• Cathy F. Rudolph · Canton, US
• Barbara J. Sullivan · Burlington, US
• Janice G. Pero · Lexington, US

Key dates

• Filing date: Apr 15, 1997
• Grant date: Feb 23, 1999
• Expiry date: Apr 15, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/75
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (RP-I) and proteolytically active residual protease II (RP-II) (mpr).