Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US5874437A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1996 |
| Grant date | Feb 23, 1999 |
| Priority date | — |
| Expiry date | Nov 1, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO.sub.n -PDE inhibitor wherein n is 1 or 2. The phosphodiesterase inhibitor can be nitrosylated or nitrosated through sites such as oxygen (hydroxyl condensation), sulfur (sulfhydryl condensation), carbon and nitrogen. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.cndot.) or which stimulates endo genous EDRF production The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a method for treating male impotence in humans by administering the compounds and compositions thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.