Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors

US5874473A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Harold C. Kluender · Madison, US
• Guenter Hans Herbert Heinz Benz · Velbert, DE
• Kerry Combs · Wallingford, US
• Brian R. Dixon · Woodbridge, US
• Michael C. VanZandt · Guilford, US
• Scott Wilhelm · Orange, US
• Donald J. Wolanin · Orange, US
• Jill Wood · Hampton, US
• Stephan Schneider · Wuppertal, DE

Key dates

• Filing date: May 28, 1997
• Grant date: Feb 23, 1999
• Expiry date: May 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the subscript "e" is 2 or 3; the group R.sup.14 represents a variety of possible substituent groups on the cycloalkyl ring between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.