Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process

US5874578A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Janak Singh · Lawrenceville, US
• Gregory S. Bisacchi · Lawrenceville, US
• Jollie D. Godfrey, Jr. · Lawrenceville, US
• Toomas Mitt · Plainsboro, US
• Richard H. Mueller · Marl, DE
• Robert Zahler · Pennington, US
• Thomas P. Kissick · Princeton, US

Key dates

• Filing date: Jan 25, 1993
• Grant date: Feb 23, 1999
• Expiry date: Jan 25, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/40
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formula EQU Z.sub.1 --X to yield the purine of the formula ##STR2## wherein x is a leaving group, and Z.sub.1 is a protected form of the carbohydrate surrogate Z. Several routes are disclosed for converting this intermediate to the antiviral agent ##STR3##