Ruthenium catalysts and their use in the asymmetric hydrogenation of cyclopentenones
US5874600A · kind A · utility
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26Claims
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Key dates
| Filing date | Jul 10, 1997 |
| Grant date | Feb 23, 1999 |
| Priority date | — |
| Expiry date | Jul 10, 2017 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/842
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A catalyst of ruthenium (II) which includes bidentate phosphine ligands. The catalyst is obtainable by a process which includes the steps of treating equimolar amounts of an appropriate Ru(II) complex and a bidentate diphosphine ligand with an acid of formula HX, wherein X is a non-coordinating anion. The acid is used in a ratio which does not exceed 2 molar equivalents per mole of Ru(II) complex and the treatment is carried out in a non-coordinating or weakly coordinating solvent and under an inert atmosphere. This catalyst is useful for the preparation of the preferred isomer of HEDIONE, having the (+)-(1R)-cis-configuration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.