Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same

US5876727A · kind A · utility

Assignee

• ImmuLogic Pharmaceutical Corporation · US

Inventors

• Philip A. Swain · Boston, US
• Victoria C. Schad · Cambridge, US
• Julia L. Greenstein · Newton, US
• Mark A. Exley · Sharon, US
• Barbara S. Fox · Wayland, US
• Stephen P. Powers · Waltham, US
• Malcolm L. Gefter · Lincoln, US

Key dates

• Filing date: Sep 30, 1996
• Grant date: Mar 2, 1999
• Expiry date: Sep 30, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.