Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies

US5876754A · kind A · utility

Assignee

• ALFATEC-Pharm GmbH · DE

Inventors

• Jens-Christian Wunderlich · Heidelberg, DE
• Ursula Schick · Schriesheim, DE
• Jurgen Werry · Ludwigshafen, DE
• Jurgen Freidenreich · Schriesheim, DE

Key dates

• Filing date: Dec 19, 1994
• Grant date: Mar 2, 1999
• Expiry date: Dec 19, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2989
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the active compound being present in a matrix in dissolved, suspended or emulsified form, and a novel process for the production of these shaped articles, the process being particularly economically and ecologically acceptable, and use of the shaped articles as medicaments, in which the bioavailability, shelf life and tolerability is increased. Using the shaped articles or mixtures according to the invention, intermediates or final products for pharmacy, cosmetics, diagnosis, analysis or dietetics (healthcare) can additionally be advantageously prepared.