Use of boron-containing polynucleotides as diagnostic agents
US5876938A · kind A · utility
68Cited by
9References
7Claims
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Key dates
| Filing date | Apr 11, 1997 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | Apr 11, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide base in a position which does not interfere with the hydrogen bonding capabilities of that base during duplex formation. The modified polynucleotides are typically formed from naturally occurring nucleotides and one or more modified nucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.