Dimer of molecular variant of apolipoprotein and processes for the production thereof
US5876968A · kind A · utility
22Cited by
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7Claims
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Key dates
| Filing date | Nov 4, 1993 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | Nov 4, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substantially pure dimers of Apolipoprotein Al-Milano (Al-M/APO Al-M) isolated and characterized from plasma are provided. Pharmaceutical compositions comprising the Apo Al-M/Apo Al-M are also provided. Apolipoprotein Al-M dimer can be produced in a recombinant Escherichia coli system or collected from plasma from Apolipoprotein Al-Milano carriers. Atherosclerosis and cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used for preventing thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.