Patent · US Expired

Chimeric adenoviral vectors

US5877011A · kind A · utility

33Cited by

1References

2Claims

0Family size

Assignee

Genzyme Corporation · US

Inventors

Donna Armentano · Belmont, US
Richard Gregory · Westford, US
Alan E. Smith · Dover, US

Key dates

Filing date	Nov 20, 1996
Grant date	Mar 2, 1999
Priority date	—
Expiry date	Nov 20, 2016

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2810/6018
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A chimeric adenoviral vector is provided that comprises nucleotide sequence of a first adenovirus, wherein at least one gene of said first adenovirus encoding a protein that facilitates binding of said vector to a target mammalian cell, or internalization thereof within said cell, is replaced by the corresponding gene from a second adenovirus belonging to subgroup D, said vector further comprising a transgene operably linked to a eucaryotic promoter to allow for expression therefrom in a mammalian cell. Additionally, a method of delivering transgenes to target mammalian cells, particularly airway epithelial cells, is provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.