Process for creating molecular diversity and novel protease inhibitors produced thereby
US5877030A · kind A · utility
1Cited by
9References
18Claims
0Family size
Inventors
Key dates
| Filing date | May 31, 1995 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for forming combinatorial libraries and the libraries produced thereby are provided. According to a preferred aspect of the invention, a plurality of core molecules are reacted with a plurality of different tool molecules to form a library of molecules having non-naturally occurring molecular diversity. The libraries are useful for identifying lead compounds which modulate the functional activity of a biological molecule. Protease inhibitors that have been isolated from the libraries also are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.