Indole derivatives useful to treat estrogen-related neoplasms and disorders
US5877202A · kind A · utility
Inventors
Key dates
| Filing date | Jan 31, 1996 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | Jan 31, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.