Aqueous phase process for preparing N-substituted imidazoles

US5877326A · kind A · utility

Assignee

• BASF SE

Inventors

• Gisela HIEBER · Heidelberg, DE
• Klaus Ebel · Lampertheim, DE
• Jürgen Schröder · Ludwigshafen, DE
• Toni Dockner
• Carsten Groning · Mannheim, DE
• Bernd Ruge · Böhl-Iggelheim, DE

Key dates

• Filing date: Aug 19, 1997
• Grant date: Mar 2, 1999
• Expiry date: Aug 19, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing substituted imidazoles of the formula I ##STR1## R.sup.1, R.sup.2 and R.sup.3 are identical or different and are each hydrogen, halogen, NO.sub.2, CN or a C.sub.1 -C.sub.20 -hydrocarbon radical which is unsubstituted or substituted by one or more halogens or R.sup.1 and R.sup.2 together are members of a 3- to 20-membered hydrocarbon ring which is unsubstituted or substituted by one or more halogens and/or C.sub.1 -C.sub.8 -alkyl groups and which may contain 1, 2 or 3 heteroatoms from the group consisting of nitrogen, oxygen and sulfur, and PA1 R.sup.4 is a C.sub.1 -C.sub.20 -hydrocarbon radical which is unsubstituted or substituted by one or more halogens, comprises using an aqueous phase of the imidazoles of the formula II ##STR2## where R.sup.1, R.sup.2 and R.sup.3 are as defined above with compounds of the formula III EQU R.sup.4 --O--R.sup.5 III where PA1 R.sup.4 is as defined above and PA1 R.sup.5 is hydrogen or R.sup.4, it being possible in the latter case for the two R.sup.4 substituents to be identical or different, and reacting it at from 200.degree. to 550.degree. C. in the presence of a catalyst comprising oxides and/or phosphates of one or more m…