Palladium catalyzed indolization
US5877329A · kind A · utility
17Cited by
2References
18Claims
0Family size
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Key dates
| Filing date | Aug 7, 1997 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | Aug 7, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Indoles of structural formula (III): ##STR1## are synthesized by the palladium-catalyzed coupling/ring closure of a 2-halo or 2-trifluoromethylsulfonyloxy aniline and an alkyl ketone derivative. The process is particularly useful to form indoles containing acid-labile substituents such as triazole, acetyl, ketal, cyano, and carbamate, or indoles having a facile leaving group in the benzyl position. The advantages of the present process are that it does not require the use of triphenyl phosphine or tetrabutyl ammonium chloride or lithium chloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.