Mice mutant for functional Fc receptors and method of treating autoimmune diseases
US5877396A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 18, 1994 |
| Grant date | Mar 2, 1999 |
| Priority date | — |
| Expiry date | Aug 18, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a domain of a human Fc receptor, as well as DNA encoding such Fc receptor-based proteins. Also disclosed are in vivo methods for identifying proinflammatory agents that depend on a functional Fc receptor, in vivo methods for identifying proinflammatory agents that do not depend on a functional Fc receptor, and both in vivo and in vitro methods of identifying anti-inflammatory agents. Pharmaceutical compositions containing, and methods of treating inflammation with anti-inflammatory agents are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.