Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors
US5879898A · kind A · utility
16Cited by
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13Claims
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Key dates
| Filing date | May 17, 1995 |
| Grant date | Mar 9, 1999 |
| Priority date | — |
| Expiry date | May 17, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70585
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is marked over-expression of multiple spliced variants of the CD44 gene in tumor compared to counterpart normal tissue. This observation forms the basis of a method of diagnosing neoplasia by analysis of a sample of body tissue or body fluid or waste product. A new exon 6 of 129 bp has been located and sequenced. Antibodies specific to the exon have been prepared and are claimed as new compounds suitable for use in the detection of CD44 proteins and for the in vivo imaging and therapy of tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.