Artificial gene coding for authentic human serum albumin, use thereof and method
US5879907A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | May 13, 1992 |
| Grant date | Mar 9, 1999 |
| Priority date | — |
| Expiry date | May 13, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/765
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A structural gene coding for authentic human serum albumin, --optionally supplemented by an upstream triplet coding for methionine and optionally extended by a synthetic prepro.sup.x -leader-coding sequence--, wherein the codons of the nucleotide sequence have been selected with regard to a non-human host, e.g. yeast, chosen for expression of authentic human serum albumin, is disclosed. Additionally there is disclosed a method of producing said gene. There are also disclosed a recombinant DNA molecule comprising said strucural gene inserted into a vector, and a host transformed with said recombinant DNA molecule. Furthermore there are disclosed a method of producing authentic human serum albumin, an authentic human serum albumin resulting from said method, and a pharmaceutical composition comprising said resulting human serum albumin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.