High molecular weight polymer-based prodrugs
US5880131A · kind A · utility
173Cited by
21References
44Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 29, 1995 |
| Grant date | Mar 9, 1999 |
| Priority date | — |
| Expiry date | Sep 29, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
High molecular weight, water-soluble prodrugs of the formula: ##STR1## wherein: D is a biologically active moiety; PA1 M is X or Q; PA1 X is an electron withdrawing group; PA1 Q is a moiety containing a free electron pair positioned five or six atoms from Y'; PA1 Y and Y' are oxygen or sulfur; PA1 R is a polyalkylene oxide; and PA1 Z is OH, C.sub.1-4 all moieties or ##STR2## are disclosed. In preferred embodiments, the prodrugs contain a polyethylene glycol having a molecular weight of at least about 20,000.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.