Derivatives of tetramethylcyclopropane

US5880157A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Jeff Sterling · Jerusalem, IL
• Yaacov Herzig · Raanana, IL
• Meir Bialer · Jerusalem, IL
• Abdullah Haj-Yehia · Jerusalem, IL
• Boris Yagen · Jerusalem, IL

Key dates

• Filing date: Nov 25, 1996
• Grant date: Mar 9, 1999
• Expiry date: Nov 25, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid (TMCA) of general formula (I), ##STR1## wherein R is lower alkyl group (C.sub.1 -C.sub.6), an aryl group, an aralkyl group or an amide of general formula (II), ##STR2## where R.sub.1 and R.sub.2 are the same or different and may be hydrogen, a alkyl group (C.sub.1 -C.sub.6), an aryl group or an aralkyl group, and n=0-3, to their racemic mixtures and the D and L enantiomers. The invention also relates to processes for the preparation of said compounds and for pharmaceutical preparations comprising the same. The new compounds show improved activity against epilepsy.