Peptide compounds

US5882645A · kind A · utility

Assignee

• The School of Pharmacy, University of London · GB

Inventors

• Istvan Toth · Brisbane, AU
• William Anthony Gibbons · Kennington, GB

Key dates

• Filing date: Mar 13, 1995
• Grant date: Mar 16, 1999
• Expiry date: Mar 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/32122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic peptides are widely used to generate antibodies. To induce high antibody response, it is known to conjugate the peptide to a carrier protein (e.g. KLH, BSA) or to incorporate it into polylysine to form a multiple antigenic peptide. Anchors may be built in which are based on fatty acids. According to the invention there is provided a novel lipidic amino acid based anchor system which can maximally enhance the antigenicity of a short synthetic peptide. These novel compounds are entirely peptide-based and may therefore be produced automatically by some step wise peptide synthesis, preferably solid phase step wise peptide synthesis. According to the invention there is also provided such a process.