Substituted cinnamic acid guanidides, a process for their preparation, their use as medicaments or diagnostic agents and medicaments comprising them

US5883133A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Jan-Robert Schwark · Frankfurt am Main, DE
• Joachim Brendel · Bad Vilbel, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Hans-Jochen Lang · Hofheim, DE
• Andreas Weichert · Egelsbach, DE
• Udo Albus · Florstadt, DE
• Wolfgang Scholz · Beverly, US

Key dates

• Filing date: Jul 24, 1996
• Grant date: Mar 16, 1999
• Expiry date: Jul 24, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## are described in which at least one of the substituents R(1), R(2), R(3), R(4) and R(5) is a nitrogen-containing heterocyclic radical. They are outstanding cardiovascular therapeutic agents. They are obtained by reaction of a compound II ##STR2## with guanidine.