Process for N-desmethylating erythromycins and derivatives thereof

US5883236A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• John E. Hengeveld · Kenosha, US
• Xiaoxing Dong · Lancaster, US
• Ashok K. Gupta · Jülich, DE
• Richard Copp · Oregon, US
• Ramiya H. Premchandran · Gurnee, US

Key dates

• Filing date: Nov 19, 1997
• Grant date: Mar 16, 1999
• Expiry date: Nov 19, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.