Synthesis of polypyrrolic macrocycles from meso-substituted tripyrrane compounds
US5883246A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1996 |
| Grant date | Mar 16, 1999 |
| Priority date | — |
| Expiry date | Mar 7, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of Formula I: ##STR1## wherein: Q represents identical alkyl groups, cycloalkyl groups having from 5 to 7 ring atoms, or aryl or heteroaryl groups having from 5 to 12 ring atoms and PA1 R represents identical hydrogen, alkyl, alcohol or carbonyl-containing groups; or a composition containing from 5 to 100 mole % by weight of the compound of Formula I. A novel method for synthesizing the compound of Formula I comprises the steps of: (a) reacting a compound of the formula: EQU Q--CHO or Q--CH(OS)(OS') PA2 wherein Q is as defined above and PA2 S and S' are independently lower alkyl, an aryl group containing from 5 to 14 ring atoms, and --(CH.sub.2).sub.n -- where n=2-4, with an excess amount of a pyrrole in the presence of a catalytic amount of a strong Lewis or Bronsted acid; PA1 (b) removing any unreacted pyrrole or other solvents used by evaporation; PA1 (c) removing polymeric materials and removing the corresponding dipyrromethane by-product, leaving the compound of Formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.