Process for making phenyl heterocycles useful as cox-2 inhibitors

US5883267A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Kai Rossen · Hanau, DE
• Ralph P. Volante · Rahway, US
• Guo-Jie Ho · Scotch Plains, US
• Roger N. Farr · Whitehouse Station, US
• David J. Mathre · Skillman, US

Key dates

• Filing date: May 6, 1997
• Grant date: Mar 16, 1999
• Expiry date: May 6, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/60
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##