Selective thyroid hormone analogs

US5883294A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Thomas S. Scanlan · San Francisco, US
• Grazia Chiellini · Madison, US
• Hikari A.I. Yoshihara · San Francisco, US
• James Apriletti · Berkeley, US
• John D. Baxter · West Melbourne, US
• Ralff C. J. Ribeiro · San Francisco, US

Key dates

• Filing date: Jun 18, 1997
• Grant date: Mar 16, 1999
• Expiry date: Jun 18, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C59/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Selective thyroid hormone agonists are disclosed that are highly selective for the TR.beta. subtype with high binding affinity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.