Pharmaceutical controlled release tablets containing a carrier made of cross-linked amylose and hydroxypropylmethylcellulose
US5885615A · kind A · utility
14Cited by
13References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1996 |
| Grant date | Mar 23, 1999 |
| Priority date | — |
| Expiry date | Aug 19, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/209
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a pharmaceutical controlled release tablet containing an active ingredient in combination with a carrier made of cross-linked amylose in which hydroxymethylpropylcellulose (HPMC) with a viscosity higher than or equal to 4000 cps is added as an adjuvant. The addition of HPMC to the tablet permits to control the effect of enzymes, and more particular alpha-amylase present in the intestinal medium, on the cross-linked amylose used as a carrier, and thus to reduce the dependence of the kinetics of release upon the concentration of enzymes present in the medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.