Method of screening of substances for their effect on the expression of mediators of inflammation in a hair follicle
US5885766A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 11, 1997 |
| Grant date | Mar 23, 1999 |
| Priority date | — |
| Expiry date | Sep 11, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/5412
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An assay for determining whether a first substance is potentially suitable for use as an active agent in hair treating compositions is provided. This assay involves contacting a first substance having putative activity as an active agent for treating hair with plucked hair follicle contained in a culture medium and assaying for a second substance which is correlated to the potential efficacy of the first substance. This assay is particularly suitable for use in evaluating the potential efficacy of hair growth promoters, hair growth retardants, agents that affect hair color, agents that affect hair survival and agents that affect inflammation. This assay is especially suited for evaluating putative efficacy of agents for treatment and/or prevention of the inflammatory stages of alopecia. In particular, the compound to be quantitatively determined is a mediator of inflammation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.