Biotin operon
US5885792A · kind A · utility
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Key dates
| Filing date | Sep 14, 1992 |
| Grant date | Mar 23, 1999 |
| Priority date | — |
| Expiry date | Sep 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A DNA sequence of high biotin operon-expression system usable for breeding a bacterium having excellent biotin productivity is provided. A DNA sequence of biotin operon characterized in the fact that at least one base pair of either a nucleotide sequence of the regulatory region of the biotin operon of Escherichia coli or a nucleotide sequence in the vicinity of the bioB initiating codon is mutated in comparison with that of the one in its wild type strain is provided. Escherichia coli transformed with a recombinant plasmid carrying such a DNA sequence has high biotin-productivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.