Methods of expressing angiostatic protein
US5885795A · kind A · utility
57Cited by
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20Claims
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Assignee
Inventors
Key dates
| Filing date | Apr 26, 1995 |
| Grant date | Mar 23, 1999 |
| Priority date | — |
| Expiry date | Apr 26, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of a murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.