Nucleic acid constructs for the cell cycle-regulated expression of genes and therapeutic methods utilizing such constructs

US5885833A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rolf Mueller · Ingolstadt, DE
• Joerk Zwicker · Marburg, DE
• Hans-Harald Sedlacek · Marburg, DE

Key dates

• Filing date: Feb 13, 1997
• Grant date: Mar 23, 1999
• Expiry date: Feb 13, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/85
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid constructs comprising an activator sequence, a promoter module, and a structural gene are disclosed. The promoter module comprises a a CHR region and a nucleic acid sequence that binds a protein of the E2F family. These constructs are used in gene therapy, such as the treatment of disorders characterized by excess cell proliferation.