Use of isoxazole and crotonamide derivatives for the treatment of carcinomatous disorders

US5886033A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wilfried Schwab · Altentreptow, DE
• Jorg Czech · Marburg, DE
• Klaus Boslett · Marburg, DE

Key dates

• Filing date: Oct 16, 1996
• Grant date: Mar 23, 1999
• Expiry date: Oct 16, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use of isoxazole and crotonamide derivatives for the treatment of carcinomatous disorders The compound of the formula I or II ##STR1## is suitable for the production of a pharmaceutical for the treatment of carcinomatous disorders, where R.sup.1 is (C.sub.3 -C.sub.5)-cycloalkyl, (C.sub.2 -C.sub.6)-alkenyl or (C.sub.2 -C.sub.6)-alkynyl, R.sup.2 is CF.sub.3, OCF.sub.3, SCF.sub.3, OH, NO.sub.2, halogen, benzyl, phenyl, CN or O-phenyl, R.sup.3 is (C.sub.1 -C.sub.4)-alkyl, halogen or a hydrogen atom and X is a --CH group or a nitrogen atom.