Compounds useful for the synthesis of dolastatin analogs

US5886147A · kind A · utility

Assignee

• BASF SE

Inventors

• Wilhelm Amberg · Ludwigshafen, DE
• Harald Bernard · Bad Dürkheim, DE
• Ernst Buschmann · Ludwigshafen, DE
• Andreas Haupt · Ludwigshafen, DE
• Lothar Janitschke · Kleinniedesheim, DE
• Bernd Janssen · Ludwigshafen, DE
• Ulrich Karl · Havelsee, DE
• Andreas Kling · Mannheim, DE
• Stefan Muller · Weil am Rhein, DE
• Bernd de Potzolli · Bad Dürkheim, DE
• Kurt Ritter · Heidelberg, DE
• Marco Thyes
• Thomas Zierke · Böhl-Iggelheim, DE

Key dates

• Filing date: Nov 6, 1996
• Grant date: Mar 23, 1999
• Expiry date: Nov 6, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/101
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.