L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo2.2.1!heptane compound and the preparation of 2-azabicyclo2.2.1!heptane compounds
US5886192A · kind A · utility
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3Claims
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Key dates
| Filing date | Jun 10, 1997 |
| Grant date | Mar 23, 1999 |
| Priority date | — |
| Expiry date | Jun 10, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the preparation of a lactam compound of formula ##STR1## wherein R'.sub.1 and R".sub.1 independently are acyl or aroyl, or taken together form an optionally substituted methylene, and G.sub.1 is hydrogen or an amino protecting group, comprising oxidizing a bis O-protected 1R-2-azadihydroxybicyclo-2.2.1!heptane compound of formula ##STR2## with about 0.1 mol % to about 1 mol % of RuO.sub.2 or hydrate thereof in the presence of about 3 equivalents of an oxidant to form the lactam compound with an enantiomeric excess of greater than or equal to about 95%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.