Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation

US5888497A · kind A · utility

Assignee

• THE ROGOSIN INSTITUTE · US

Inventors

• Kanti Jain · Briarcliff Manor, US
• Albert L. Rubin · Englewood, US
• Shirin Asina · New York, US
• Barry Smith · New York, US
• Kurt Stenzel · Englewood, US

Key dates

• Filing date: Nov 7, 1996
• Grant date: Mar 30, 1999
• Expiry date: Nov 7, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2035/126
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Implantable beads which contain agarose and optionally collagen, and are coated with agarose have incorporated within cells which produce diffusible biological products. The beads may be used as implants to modulate a recipient's immune response. The beads may also be used in an in vitro context to encourage specific types of cells to grow, to produce desirable products in culture, or to suppress growth of certain cells. The implants may also suppress growth of certain cells following administration to a subject. Cancer cells such as renal cancer cells when restricted by being entrapped in the beads produce more of a material that suppresses cancer cell proliferation.