Method of inhibition of nucleo-cytoplasmic transport by M protein of vesicular stomatitis virus
US5888727A · kind A · utility
3Cited by
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17Claims
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Key dates
| Filing date | May 21, 1997 |
| Grant date | Mar 30, 1999 |
| Priority date | — |
| Expiry date | May 21, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of inhibiting transport of nucleic acids between the nucleus and cytoplasm of a cell is disclosed. In one embodiment, this method comprises the step of exposing a cell to a sufficient amount of vesicular stomatitis virus M protein such that the transport of RNA and protein through the nuclear envelope of the cell is impeded. A chimeric RNA capable of nuclear export is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.