Substituted amino alkyl compounds

US5889011A · kind A · utility

Assignee

• CELLO THERAPEUTICS, INC. · US

Inventors

• J. Peter Klein · Vashon, US
• Gail E. Underiner · Malvern, US
• Alistair J. Leigh · Edmonds, US

Key dates

• Filing date: Jun 27, 1997
• Grant date: Mar 30, 1999
• Expiry date: Jun 27, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds and pharmaceutical compositions thereof comprise the formula: EQU (R)j- (core moiety), including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein J is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring structure, R may be selected from the group consisting of hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted benzyl, alkyl (C.sub.1-6) or alkenyl (C.sub.1-6), and at least one R has the formula I: ##STR1## wherein n is an integer from four to eighteen; each R'.sub.1 and R'.sub.2 is independently hydrogen, alkyl (C.sub.1-4) or alkenyl (C.sub.1-4), the alkyl or alkenyl groups being preferably substituted by a halogen, hydroxyl, ketone or dimethylamino group and/or may be interrupted by an oxygen or hydrogen atom or an alkyl (C.sub.1-4) group; and each R'.sub.3 and R'.sub.4 is independently hydrogen or methyl. Preferably, n is an integer from six to ten, R'.sub.1 and R'.sub.2 are independently hydrogen or methyl and R'.sub.3 and R'.sub.4 are hydrogen. The compounds are useful in treating or preventing, for example, sepsis syndrome, hematopoietic or o…