Pharmacologically active catechol derivatives

US5889037A · kind A · utility

Assignee

• Orion-Yhtyma OY · FI

Inventors

• Reijo Backstrom · Helsinki, FI
• Erkki J. Honkanen · Vantaa, FI
• Inge-Britt Y. Linden · Espoo, FI
• Erkki A. O. Nissinen · Espoo, FI
• Aino K. Pippuri · Espoo, FI
• Pentti Pohto · Helsinki, FI
• Tapio Korkolainen · Helsinki, FI

Key dates

• Filing date: Jun 7, 1995
• Grant date: Mar 30, 1999
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## Compounds of formula (I), wherein R.sub.1 is an electronegative substituent such as nitro, halogeno or cyano group and R.sub.2 is a group selected from (Ia) and (Ib), wherein R is hydrogen, or an alkyl, cycloalkyl, aralkyl or aryl group, wherein X.sub.1, X.sub.2, Y and Z are independently oxygen, sulfur of NR, wherein R may be as defined above and pharmaceutically acceptable esters and salts thereof are useful in the prevention or treatment of tissue damage induced by lipid peroxidation.