Protein or polypeptide, method for producing the same and intermediate compound therefor
US5889153A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 1997 |
| Grant date | Mar 30, 1999 |
| Priority date | — |
| Expiry date | Mar 14, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a protein or polypeptide substance having at least one amino group bonded to a polyethyleneglycolosy group represented by the following general formula; EQU R.sub.1 --(OCH.sub.2 CH.sub.2).sub.n --O-- (wherein R.sub.1 represents an optionally substituted cholesteryl group; and n represents a positive integer which is arbitrarily variable), and a method for producing said the protein or polypeptide. The present invention also provides a reactive polyethyleneglycol derivative as an intermediated for above the method. The chemically modified protein or polypeptide of the present invention never impairs bonding with a receptor and has a high plysiological activity. Then, a behaviors in vivo of these substance is improved. Now medical substances or drugs having a high pharmacological activity can be developed by using these substance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.