Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
US5889186A · kind A · utility
7Cited by
2References
24Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 16, 1994 |
| Grant date | Mar 30, 1999 |
| Priority date | — |
| Expiry date | Dec 16, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid undesired losses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.