Monoclonal antibodies to the APO-1 antigen

US5891434A · kind A · utility

Assignee

• Centocor, Inc. · US

Inventors

• Peter Krammer · Heidelberg, DE
• Klaus-Michael Debatin · Heidelberg, DE
• Bernhard Trauth · Waldshut-Tiengen, DE
• Iris Behrmann · Heidelberg, DE
• Jens Dhein · Trier, DE
• Christiane Klas · Lörrach, DE
• Peter Moller · Heidelberg, DE
• Werner Falk · Nittendorf, DE
• Alexander Oehm · Wiesbaden, DE
• Peter T. Daniel · Reutlingen, DE

Key dates

• Filing date: Mar 23, 1995
• Grant date: Apr 6, 1999
• Expiry date: Mar 23, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/73
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The APO-1 cellular membrane antigen, an about 50 kDa antigen associated with cellular apoptosis, and purified cDNA encoding same is described. The antigen is expressed by numerous normal and malignant cells, including activated and malignant lymphoid cells. Also disclosed are antibodies which bind the antigen, and which induce growth inhibition and apoptosis.