Enhancement of vascular function by modulation of endogenous nitric oxide production or activity

US5891459A · kind A · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• John Cooke · Palo Alto, US
• Victor J. Dzau · Newton, US
• Gary H. Gibbons · Atlanta, US

Key dates

• Filing date: Nov 9, 1995
• Grant date: Apr 6, 1999
• Expiry date: Nov 9, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds, namely L-arginine, L-lysine, physiologically acceptable salts thereof, and polypeptide precursors thereof, which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. In or in combination, other compounds, such as B.sub.6, folate, B.sub.12, or an antioxidant, which provide for short term enhancement of nitric oxide, either directly or by physiological processes may be employed.