Solid Coprecipitates for enhanced bioavailability of lipophilic substances
US5891469A · kind A · utility
127Cited by
19References
22Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 2, 1997 |
| Grant date | Apr 6, 1999 |
| Priority date | — |
| Expiry date | Apr 2, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/146
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lipophilic active ingredients are co-melted with tocopherol polyethyleneglycol succinate (TPGS) and a dispersion adjuvant to obtain solid dry coprecipitate compositions suitable as an oral dosage form. The solid TPGS coprecipitates of lipophilic active ingredients show improved drug release in vitro and enhanced oral bioavailability in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.