Methods of using domains of extracellular region of human platelet-derived growth factor receptor polypeptides

US5891652A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• David L. Wolf · Palo Alto, US
• James E. Tomlinson · Horsham, GB
• Larry J. Fretto · Palo Alto, US
• Neill A. Giese · San Francisco, US
• Jaime Escobedo · San Francisco, US
• Lewis T. Williams · San Francisco, US

Key dates

• Filing date: Jun 2, 1995
• Grant date: Apr 6, 1999
• Expiry date: Jun 2, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.