Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)
US5891664A · kind A · utility
10Cited by
2References
22Claims
0Family size
Assignee
Inventors
- Keld Dan.o slashed.
- Francesco Blasi
- Ann Louring Roldan
- Maria Vittoria Cubellis
- Maria Teresa Masucci
- Ettore Appella
- Wolf-Dieter Schleuning
- Niels Behrendt
- Ebbe R.o slashed.nne
- Peter Kristensen
- Jari Pollanen
- Eeva-Marjatta Salonen
- Ross Stephens
- Hannele Tapiovaara
- Antti Vaheri
- Lisbeth Birk M.o slashed.ller
- Vincent Ellis
- Leif R.o slashed.ge Lund
- Michael Ploug
- Charles Pyke
- Laszlo Patthy
Key dates
| Filing date | Oct 6, 1994 |
| Grant date | Apr 6, 1999 |
| Priority date | — |
| Expiry date | Oct 6, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9723
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.