Polynucleotides encoding GTP cyclohydrolase II (ribA)

US5891672A · kind A · utility

Assignees

• SmithKline Beecham Limited · US
• SmithKline Beeacham P.L.C. · GB

Inventors

• Min Wang · Blue Bell, US
• Judith M Ward · Dorking, GB
• Richard Lloyd Warren · Grantsville, US
• Richard Oakley Nicholas · Collegeville, US
• Leslie Marie Palmer · Audubon, US
• Julie M Pratt · Wigston, GB
• David Justin Charles Knowles · Boroughbridge, GB
• Michael Arthur Lonetto · Collegeville, US
• Jeffrey Mooney · Limerick, US
• Michael Terence Black · Le Vésinet, FR
• Martin Karl Russel Burnham · Norristown, US
• Christine Debouck · Wayne, US
• Jason Craig Fedon · Strafford, US
• John Edward Hodgson · Malvern, US
• Deborah Dee Jaworski · West Chester, US
• Raymond Winfield Reichard · Quakertown, US
• Martin Rosenberg · Royersford, US
• Christopher Michael Traini · Media, US
• Yi Yi Zhong · Audubon, US

Key dates

• Filing date: Nov 25, 1997
• Grant date: Apr 6, 1999
• Expiry date: Nov 25, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.