TNF-alpha muteins and a process for preparing them
US5891679A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1995 |
| Grant date | Apr 6, 1999 |
| Priority date | — |
| Expiry date | Sep 15, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to tumor necrosis factor muteins characterized in that the TNF-.alpha. amino acid sequence is mutated, or deleted totally or partially, in the region containing position 101 to 116 in such a way that: PA1 either the lectin-like activity is reduced with respect to TNF-.alpha., PA1 or the toxic activity is reduced with respect to TNF-.alpha.; and providing that said muteins have largely retained the tumoricidal activity of TNF-.alpha.; and with said muteins possibly containing in their peptidic chain additional modifications consisting of substitutions and/or deletions and/or additions of one or several amino acid residues, and with said muteins being characterized in that they have retained the aforementioned activities; or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.