Compositions for cytochrome P450 biotransformation reactions
US5891696A · kind A · utility
7Cited by
0References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 1, 1997 |
| Grant date | Apr 6, 1999 |
| Priority date | — |
| Expiry date | Aug 1, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/004
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A storable biotransformation mixture that can oxidize a drug, comprising a cytochrome P450 enzyme, an electron donor; and, a buffer solution. In a preferred embodiment the mixture also contains liposomes, cytochrome b.sub.5 and NADPH-P450 reductase as the electron donor. The mixture is storable at a temperature less than 8.degree. C. to for at least two weeks and is able to oxidize a drug after storage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.