Anti-viral compound

US5891874A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Joseph Matthew Colacino · Indianapolis, US
• Beverly Ann Heinz · Bargersville, US
• Louis Nickolaus Jungheim · Indianapolis, US
• Shawn Christopher Miller · Indianapolis, US
• Wayne A. Spitzer · Indianapolis, US
• Joseph Chiou-Chung Tang · Carmel, US
• Mark J. Tebbe · Hamburg, DE
• Frantz Victor · Indianapolis, US

Key dates

• Filing date: Jun 4, 1997
• Grant date: Apr 6, 1999
• Expiry date: Jun 4, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A series of benzimidazole compounds having the following general structure are provided which inhibit the growth of picornaviruses (e.g., rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus) and flaviviruses (e.g., hepatitis C and bovine diarrheal virus). ##STR1## A method for inhibiting picornaviruses and flaviviruses is also provided which includes administering to a host an effective amount of the inventive benzimidazole compounds.