Vector for gene transfer in liver cells

US5895759A · kind A · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Michael Strauss · Hillsboro, US
• Volker Sandig · Berlin, DE
• Christian Hofmann · Erlangen, DE

Key dates

• Filing date: Sep 3, 1996
• Grant date: Apr 20, 1999
• Expiry date: Sep 3, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2730/10122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A tissue-specific, suitably liver specific vector for gene therapy of a diseased host, wherein a therapeutic gene is coupled to a promoter chemically, enzymatically, or over an antibody, packaged in a polypeptide coat, and coupled to a component of a preselected virus of the tissue to be treated, and when the tissue is liver tissue, then the virus is hepatitis B virus.